The actress in the Centrum commercial “Fascinating Facts” from 2016 is:
Mindy’s IMDB Page
Mindy is a longtime Hollywood actress who is well known for her role as Frau Farbissina in the Austin Powers series. Mindy has been a member of the highly respected Groundlings Improv Troupe since 1984.
The voice over in the Centrum commercials is provided by Martin Sheen.